pert diagram
PERT diagram (Click to zoom)

MIROCALS aims to perform a novel intervention study with the potential to:

  • halt disease progression
  • test the proof of concept that biomarkers can accelerate future intervention studies
  • provide unique insights on disease pathogenesis identifying novel targets for intervention.

The workprogramme has been structured in 7 workpackages (WPs):

WP2 and WP3 relate to the performance of the clinical trial

Work package 2: Clinical trial implementation
WP2 aim at designing, getting approval and organizing the clinical trial.

Work package 3: Clinical trial conduct
In this WP, the clinical trial will be carried out in compliance with GCP/GCLP rules, to demonstrate the efficacy and safety of ultra-low-dose IL-2 for patients with recently diagnosed ALS.

WP4, WP5 and WP6 relate to the specific laboratory investigations using CSF and blood samples collected during the trial to get better insights into the effects of riluzole and low dose IL-2 in ALS patients.

Work package 4: Deep immuno-phenotyping
WP4 aims to establish the effect of low dose IL-2 on key effectors and regulators of the neuro-inflammatory process and establish their relationship with treatment responses and disease activity.

Work package 5: Brain Biomarkers
The main focus of this WP will be on neurofilaments, whose dynamic of release into biological fluids reflects the progressive cytoskeletal break-down of neurons and axons.

Work package 6: Genomics and Transcriptomics
The main objective of WP6 is to establish the changes in transcriptomic profiles in response to both riluzole and IL-2 treatment and to characterise the gene expression signatures of responders to IL-2 versus those of non-responders.

WP1 and WP7 will ensure the project management as well as organizing the dissemination of the project’s results to patients and other stakeholders.

News

7th ExCom, Autumn 2019

The 7th Executive Committee Meeting will be held next autumn to discuss about the progress since the last meeting and to plan the next activities.

6th ExCom, March 2019

The 6th Executive Committee Meeting took place on 15th March 2019 to discuss about the progress since the last meeting and to plan the next activities.

MIROCALS 2nd General meeting in Milan, June 2018

The last consortium meeting of MIROCALS was held on June 7th and 8th 2018 in Milan to present the progress made since the beginning of the project. 

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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 633413.